The Upson House, also known as the Franklin-Gazaway-Long-Upson House or the Dr. Marcus A. Franklin House, is located at 1022 Prince Avenue (Tax Parcel No. 11-4-D3-A-017).
 

This two-story Greek Revival style residence features a central hall plan with a four-over-four room arrangement. A full-facade Doric portico shelters a lighted, trabeated doorway, which displays sidelights, a transom, and framing pilasters. Details of roof design and proportion avoid the usual horizontal emphasis; the high hip roof, visible above the Ionic entablature, and the narrow triple-sash windows, lend a vertical air to the building. Other features include a stuccoed-brick exterior scored to resemble stone and the absence of a hanging balcony. Quarter-sawn parquet floors of oak with mahogany and rosewood borders date to the 1890s. Adaptively used as a bank, the building now has a vault and a rear addition for drive-in service where the residential rear addition once stood. The lot retains, however, its large magnolia trees and circular drive.

The building was constructed in 1847 for a Macon physician, Dr. Marcus A. Franklin, who subsequently sold it to Gazaway Lamar in April 1848. James Long, the father of Crawford W. Long (the first physician to use ether as an anesthetic), later acquired the house. Steven Upson, son of the Steven Upson for whom Upson County was named, purchased the residence in 1885. After completing his undergraduate degree at Yale, the younger Upson studied medicine and law and was admitted to practice law before the Georgia Supreme Court in 1846. The house remained in the Upson family through four generations; the last family member to occupy the house was Mrs. Bradbury Foss, granddaughter of the founder of the first garden club in America. The First National Bank of Athens, currently SunTrust Bank, acquired the property in 1974 and began renovation efforts in 1979. The adaptive use retained the original fabric and detailing of the building, converted the upper floor to offices and conference space and the main floor into the bank itself, constructed the rear additions while mitigating their visibility from the street, and salvaged the tree-shaded lot.

The Upson House was documented by the Historic American Buildings Survey (GA-14-66), is listed on the National Register of Historic Places (November 15, 1973), and has been locally designated as a Historic Landmark (November 1, 1988).